Bioactive Small Molecules
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Filtered Search Results
Cayman Chemical BAR501, Purity: ≥95%, CAS: 1632118-69-4, 25 mg
A selective GP-BAR1 agonist (EC50 = 1 μM); reduces hepatic perfusion pressure and counteracts norepinephrine-induced vasoconstriction in naïve rats; protects against development of endothelial dysfunction by increasing CSE expression and activity and reducing ET-1 gene expression in rat model of cirrhosis; increases Akt-dependent phosphorylation of CSE and eNOS and inhibits ET-1 transcription in vitro; reduces trinitrobenzenesulfonic acid-induced colitis in mice in a dose-dependent manner
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Medchemexpress LLC HY-115461 5mg Medchemexpress, MID-1 CAS:312608-54-1 Purity:>98%
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Medchemexpress, HY-115461 5mg MID-1 CAS:312608-54-1 MID-1 is a disruptor of MG53-IRS-1 (Mitsugumin 53-insulin receptor substrate-1) interaction. MID-1 disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC FLT3-IN-19 | 2237234-48-7 | C₂₂H₂₆N₈O | 5 MG
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FLT3-IN-19 (Comp 50) is a potent and selective FLT3 inhibitor with an IC50 of 0.213 nM. It can be used in AML disease research.
- Potent and selective FLT3 inhibitor (IC50 of 0.213 nM)
- Suitable for AML disease research
- Purity of 99.19%
- Appearance as a solid
- Color ranges from off-white to light yellow
- Targets FLT3
- Part of the protein tyrosine kinase/RTK pathway
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Cayman Chemical SKPin C1, Purity: ≥98%, CAS: 432001-69-9, 25 mg
An inhibitor of Skp2-mediated p27 degradation; blocks ubiquitylation of p27 in a Cks1-dependent manner in vitro at 50 μM; increases nuclear accumulation of p27 in ECC-1 endometrial carcinoma cells
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Cayman Chemical ANTIBODY ND-336 500ug
A selective inhibitor of the gelatinases MMP-2 and MMP-9, as well as MMP-14 (Kis = 85, 150, and 120 nM, respectively); accelerates diabetic wound healing in mice
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Medchemexpress LLC HY-100540 10mg Medchemexpress, Golgicide A CAS:1139889-93-2 Purity:>98%
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Medchemexpress, HY-100540 10mg Golgicide A CAS:1139889-93-2 Golgicide A is a potent, highly specific, and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF), GBF1. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Cayman Chemical TAS 120, Purity: ≥98%, CAS: 1448169-71-8, 10 mg
An orally bioavailable inhibitor of FGFRs that irreversibly inhibits all four FGFR subtypes at nanomolar concentrations; blocks the proliferation of human cancer cell lines with FGFR gene abnormalities
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Medchemexpress LLC CDCP1 Mouse Biotin 50ug | 50ug
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The CDCP1 protein has been implicated in cell adhesion and matrix association suggesting a role in important cellular interactions Its phosphorylation suggests a dynamic function in regulating anchorage migration proliferation or differentiation CDCP1 Protein Mouse (Biotinylated HEK293 His-Avi) is the recombinant mouse-derived CDCP1 protein expressed by HEK293 with C-Avi C-His labeled tag
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Medchemexpress LLC E0924G | 2909474-29-7 | 99.2% | 232.24 | 1 ML
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E0924G is an orally active activator for PPARδ with an EC50 of 2.82 μM. It promotes the upregulation of osteoprotegerin (OPG) with an EC50 of 0.29 μM. E0924G reduces RANKL-induced osteoclast differentiation and inhibits F-actin ring formation in RAW264.7 macrophages. It also regulates bone density and bone loss in ovariectomized (OVX) and age-related osteoporosis models.
- Orally active activator for PPARδ
- Promotes upregulation of osteoprotegerin (OPG)
- Reduces RANKL-induced osteoclast differentiation
- Inhibits F-actin ring formation in RAW264.7 macrophages
- Regulates bone density and bone loss
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Selleck Chemical LLC Anhydroicaritin S9080-1MG
Anhydroicaritin (Cycloicaritin) a prenylated flavonoid natural product is commonly recognized as one of the effective compounds of Epimedii Herba and exhibits a variety of biological activities such as activation of cancer cell apoptosis and inhibition of growth protection against beta amyloid-induced neurotoxicity and promotion of neuronal and cardiac cellular differentiation It is a potent inhibitor of transcription factor SREBPs
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Medchemexpress LLC HY-131335 5mg Medchemexpress, p38α inhibitor 2 CAS:1095003-80-7 Purity:>98%
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Medchemexpress, HY-131335 5mg p38α inhibitor 2 CAS:1095003-80-7 p38α inhibitor 2 is a highly potent and selective p38α MAPK inhibitor, with a pIC50 of 9.6. p38α inhibitor 2 inhibits the hERG ion channel (IC50=27 μM) and shows a promising selectivity profile when tested in a panel of 51 other protein kinases (<30% inhibition at 10 μM concentration) and a panel of 141 other biological targets. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC 2'-Deoxy-5-methylisocytidine | 19316-88-2 | C10H15N3O4 | 100 MG
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2'-Deoxy-5-methylisocytidine | 19316-88-2 | C10H15N3O4 | 100 MG
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Medchemexpress LLC Butyzamide | 1110767-45-7 | 99.8% | 591.55 | 1 MG
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Butyzamide is an orally active activator of Mpl, a thrombopoietin (TPO) receptor. It increases the phosphorylation level of JAK2, STAT3, STAT5, and MAPK, and has been shown to increase platelet levels in mouse xenotransplantation assays.
- Increases phosphorylation of JAK2, STAT3, STAT5, and MAPK.
- Raises platelet levels in mouse xenotransplantation assays.
- Induces colony-forming unit-megakaryocyte and polyploid megakaryocytes.
- Orally active Mpl activator.
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Cayman Chemical PTI-3, Purity: ≥98%, 1 mg
An analytical reference standard that is structurally similar to known synthetic cannabinoids; intended for research and forensic applications
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Enzo Life Sciences Ac-WEHD-CHO (5mg)
Reversible, cell permeable inhibitor of caspase-1 and -5. Also inhibits caspase-4 and -14. Alternative name: Caspase 1 inhibitor (aldehyde), Caspase 5 inhibitor (aldehyde). Formula: C28H33N7O9. MW: 611.6. Purity: ≥90% (HPLC). Appearance: White to off-white powder. Formulation: TFA salt. Solubility: Soluble in water (10mg/ml). Long Term Storage: -20°C. Use/Stability: Solution is stable for 1 month when stored at -20°C and protected from light. Handling: Keep cool and dry.
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